Need input on this guys. Im actually not a fan of SARMS (Selective Androgen Receptor Modulators), but i've been spending time researching a few of them lately, and some interesting facts bubbled up.
The one im spending quite a bit of time researching now is Cardarine GW-501516. The drug is basically a Peroxisome Proliferator–Activated Receptor (PPAR) activator which isnt truely a SARM but is classified as one for whatever reason. Manufacturer is Glaxo Smith Kline (GSK), the drug was going in trial phases I / II and was desserted and classified as high risk in 2007 and hence shelved since then with no further progress in the clinical trials hence no chance of seeing daylight. To add insult to injury The World Anti-Doping Agency (WADA) added GW to the ban list in 2009.
Ok, dig more into the research, the drug has outstanding benefits:
1) Great for pre-diabetic folks or people with metabolic abnormalities since it stimulates receptors on skeletal muscles to pull more glucose from the blood. Fantastic effect, similar to metformin only seems more efficient at this job. Could be a great tool for carb sensitive people like myself to get away with consuming more carbs and having them "channeled" properly into skeletal muscles with less going towards fat tissue!
2) Significantly lower LDL and elevate HDL!
3) Sheds fat layers efficiently since it's a PPAR activator which increases fatty acid oxidation. This has been shown in many experiments to be effective and legit tested on obese men test subjects.
I absolulety LOVE the benefits of this drug, shit sounds like a miracle drug for many people out there. My main concern is cancer risk, which seems to be argued for and against out there equally as much. Personally i wouldnt take these benefits at the risk of cancer but if these cancer claims are fake/invalid or half-baked, then the drug is def worth a try off-cycle and ON cutting cycles!!
Link from the diabetes journal dating back to 2008 showing superb benefits listed above on GW administration:
diabetes.diabetesjournals.org/content/57/2/332.long
Link showing that the cancer concern is completely bogus, BUT the source is biased since they are affiliated with a sarms company, so im def inclined not to believe them, BUT they make good common sense to me:
evolutionary.org/gw-501516-cardarine-cancer
Any of you guys used Caradrine (GW) before? Extended period of time? Dosages? Would love to hear the opinions from you good folks out here even if you just happened to be researching the compounds, any information helps!!!