I am very interested in the synergy between Mechano Growth Factor (MGF) & IGF1 (Insulin Like Growth Factor 1), when supplemented in the form of PEG-MGF & IGF-LR3 peptides.
So research tells us:
- After mechanical loading (weight training), your levels of specific IGF-binding proteins (like IGFBP-4 are lower) , IGFBP-4 is a protein which binds to IGF-1 and inhibits its anabolic effects. Hence introducing IGF at this time is best (Post Workout) ??
- When muscle is broken down by training, the destruction of muscle tissue leaves behind something known as "satellite cells". Those satellite cells are small stem cells located within the muscle. During this process of regenerating muscle, myoblasts are formed to replace and hypercompensate for damaged/destroyed ones, and then they can either fuse with each other to form totally new myofibers or become incorporated into previously damaged (surviving) myofibers. Ultimately, if more myofibers are created than were destroyed (by training) new muscle growth is experienced.
- Since MGF is a variant of IGF-1, they bind to the same receptors.
- IGF-1 has a much stronger affinity to bind then MGF
Based on the facts above, it makes it somewhat difficult to find some "exactness" to the timing of each to ensure maximum utilization. But a bunch of routines have spiraled on the net by different people out there, some make sense, some dont.
So does it make sense to take MGF right after training to increase the satellite cell activity in the muscle , then wait an hour or so to introduce IGF to complete the process of building initiated by the MGF. Or is this cutting it too close??
Is administering IGF right after workout best since IGF-BP are low hence IGF is best utilized at the time?? But that would halt/slow down the MGF activity since IGF has a much higher affinity to bind to receptors than MGF hence will leave MGF idle?!
I was wondering if some of you folks on here have personal personal experiences and/or any publications/studies that sheds some light on this & shows some protocols to be superior to others for maximum utilization & biggest gains.