Decal-Based cycles on TRT? Novaldex vs Arimidex?

Thank you for having me. This is my first post following my introduction and reading the beginner's sticky.
So Im on 100mg/week TRT baseline. A friend of mine gave me some proviron and told me to increase my Test C to 300mg/wk. I put a ton of work in and wow! So I got geared up. Please give me advice on the following cycles, mainly Novaldex vs Arimidex. I will use HCG and always return to my TRT dose.

1) 100mg TestC/ 250mg deca/ 200mg MastE
2) 400mg TestC/ 200mg deca
3) I also have 200/10mg oxandrin I have no clue what to do with

Thank you!
 

THE MOOSE

Well-known member
I like #1 option... For me it would be less sides than #2 option. I would save your orals for next cycle or cut down! Double test than deca always gives me bad sides.. Now I keep Test very very low/not at all & deca higher w/ 1mg of propecia.

Why take propecia???? The penis requires androgenic stimulation, which unfortunately you cannot get with Nandrolone. Hence why people run high dose Testosterone with Nandrolone to counteract the sex side effects, the concentration of DHT from the testosterone has to be significantly higher than DHN from nandrolone so that DHN does not displace DHT from the receptor.

So how do we solve this issue? Im against running high testosterone with nandrolone. But there is a cure!

run 0.5mg-1mg Finasteride with your Nandrolone cycle everyday. This will inhibit a good portion of DHN. Results in 50% increase in androgenic activity and optimal stimulation of androgen receptors in androgenic tissue. This cures deca dick problem, it resolves psychological arousal (due to optimal androgen receptor stimulation in the brain)

But we are left with some issues. Once you do this, your skin will instantly get oily as fuck, you'll have acne out of no where and you lose some of the benefits of DHN. Plus, you want to fuck 24/7 and your dick agrees with you also. It seems like the dopaminergic issues resolve after the brain androgen receptors are optimally stimulated without DHN (as nandrolone will act as the parent agonist, without DHN antagonising Nandrolone).

Also, gyno symptoms would also disappear due to breast tissue estrogen receptor is antagonised by Nandrolone (no DHN to stop this).

Soo.... if we inhibit the formation of DHN, then nandrolone does not metabolise to a piss ass weak androgen in these local tissues (DHN works to antagonise nandrolones true androgenic potency as well, hence DHN actually reduces prostate size, and restores hair growth). With 5-AR inhibition, DHN does not get produced when nandrolone crosses local 5-AR tissues and thus instead would activate those local receptors much more potently.

I know.. I know.. People ask:
How will cutting out DHN increase androgenicity if there is no DHT in the system (no test). Presumably because Nandrolone itself is an agonist at DHT receptors?​





Because its the same androgen receptors everywhere. there is nothing special about androgen receptors in 5-AR expressed tissues (like hair follicles), other than that those particular tissues have 5-AR enzyme expressed - So when a substrate for 5-AR comes along to those particular areas, the 5-AR will react and reduce the androgen (testosterone in this case) to DHT. DHT binds tightly to the androgen receptor, and doesn't really like 'moving' away from the area it has been created. Here, DHT has 2-3x the binding affinity than testosterone, so it tends to take preference for the local androgen receptor, and exerts 10x the signalling, once bound.

Every anabolic steroid has an anabolic and androgenic profile. Trenbolone can bind to the same receptors as DHT, and stimulate it. Same as Anavar. Except Anavar is pretty weak in doing so.

When you take Nandrolone. it will float around and come across these tissues where 5-AR is expressed. here, nandrolone will reduce to DHN, DHN will bind to the receptor. This lowers the androgenic potency of nandrolone because of DHN's competition for the receptor - DHN is a weak androgen, nandrolone would still exert its anabolic response in muscle tissue (for example). When 5-AR is inhibited, nandrolone's true androgenic potency comes to light, and is able to bind to these receptors without competition.
Boom.. No deca Dick!!

Some interesting sources

[1] https://www.sciencedirect.com/scienc...6643280800003X

"Sub-chronic nandrolone treatment modifies neurochemical and behavioral effects of amphetamine and 3,4-methylenedioxymethamphetamine (MDMA) in rats"
  • "Analysis of the behavioral data suggests that effects of the amphetamine and MDMA are dose-dependently attenuated by AAS-treatment, paralleling DA results. In conclusion, the results of this study show that AAS-pre-treatment is able to modulate the reward-related neurochemical and behavioral effects of amphetamine and MDMA."
[2] http://onlinelibrary.wiley.com/doi/1...9.00439.x/full

"Impact of Nandrolone Decanoate on Gene Expression in Endocrine Systems Related to the Adverse Effects of Anabolic Androgenic Steroids" - This one is very interesting, it shows what enzyme systems Nandrolone downregulates and which ones are upregulated. Very very important information

[3] https://www.sciencedirect.com/scienc...6007601500014X

"Prolonged in vivo administration of testosterone-enanthate, the widely used and abused anabolic androgenic steroid, disturbs prolactin and cAMP signaling in Leydig cells of adult rats" - "The results showed that prolonged (10-weeks) intramuscular administration of testosterone-enanthate, in clinically relevant dose, significantly increased prolactin"

[4] http://onlinelibrary.wiley.com/doi/1...0.01402.x/full

"The anabolic-androgenic steroid nandrolone decanoate affects the density of dopamine receptors in the male rat brain"

[5] https://www.sciencedirect.com/scienc...04394003013685

"Increased dopamine transporter density in the male rat brain following chronic nandrolone decanoate administration"

[6] https://www.sciencedirect.com/scienc...06899305003641

"The effect of sub-chronic nandrolone decanoate treatment on dopaminergic and serotonergic neuronal systems in the brains of rats"
Just some calculations.

lets take the following into consideration.
  1. Nandrolone is a weak substrate for SHBG. So, overall, it is a much better anabolic than testosterone, even if you take the 125:37 vs 100:100 profile into consideration. therefore, there is more nandrolone per mg exogenously administered 'free' to bind to androgen receptors, than is testosterone per mg exogenously administered.
  2. Nandrolone aromatises at the rate of 20% of Testosterone.
Lets say, we produce equivalent to 70mg/wk Testosterone enanthate. Taking the molecular mass of the ester into account, you would need an optimal 500-600mg NPP (or deca) per week to produce a decent amount of estrogen (but still within limits) - remember, you need neither high or low amount of estrogen for optimal mental and dick health - we also have to take into consideration the fact of how the androgenic potency of an anabolic would also act to oppose estrogen at the estrogen receptor.

Those who have done DECA only cycles and have complained about deca-dick - here is the only and only reason:
  • You didnt front load deca. so what occured is that the first 4-5 weeks whilst the ester is peaking in the blood, you arent getting sufficient blood androgen levels (levels not high enough to provide optimal androgen and estrogen signalling).
  • and/or you arent taking suffice dose. If you arent taking testosterone with your nandrolone, it makes logical sense to use more nandrolone (500-600mg/wk)
Best method is to front load... or just take NPP! I'm out... You learned enough! Do more research & decide for yourself.
 
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THE MOOSE

Well-known member
Probably went overboard on that post, but people need to know! Lots of missinformation outhere & jokers just winging it!
 

THE MOOSE

Well-known member
Here are a few links:::
https://youtu.be/ZiC7TOolZ4E

*

https://youtu.be/8AisKoiIRmg




https://youtu.be/kLScNddgkks



https://www.taeian.com/deca-base-cyc...rone-no-sides/

https://youtu.be/3wlxvVpBid4


Also, never take Nolvadex when doing Deca or any Nor19 steroids.! It makes the progestin sides worse in some cases!
Although, everybody has a fingerprint & for some it's ok! Here is research study & decide if you want to try!

https://pubmed.ncbi.nlm.nih.gov/3978249/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC151802/

I personally avoid Nolve when doing Deca. I use clomid instead! Now..Nolva is an amazing medication especially when doing testosterone cycles and the wet steroids! I just did a test and dbol cycle and I included Nolva in the end and it worked incredible within 3 days. Meaning at the end of my cycle...Started to get a puffy nipple(size of a pea under my nipple), sex drive was declining, water retention. Within a few days pea growth under nipple started to shrink, sex drive went thru the roof, & water retention went down slightly. I always prefer Nolva over Arimidex. Although, Arimidex has it's place in situations.
 
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siegmund

Moderator
Thanks moose great write up and deca took me out. ,,lol I took me out.
i can't stress research enough I suggest a brother best know his E2, and how to control it before deca ...
Slot of these studies with deca were taking place when I was going on my hiatus.. so yes I have heard. Of cours running deca alone. .. myself to this day I stay away. . now I don't have a problem with npp . It's a short form ,kicks in quick and if you run into trouble you can abort just as quick .
I was in a world of trouble. No AI, NO DOPAMINE AGNOSTIC and I was running deca test anadrol (which some claim anadrol is also a 19 nor ) and it i..
Wow bad time for me. That's when I crawled in here and milkin,and a few others took the time and had the care to honestly help me instead of grimding me up ..and I tried to always play it forward ..
 

THE MOOSE

Well-known member
seigmund That's why I like this forum better than the others.. The other sites have trolls, shaming, & badgering! Nobody needs that... we all just want to learn knowledge & hear others stories/advice! I just wish more people would come to MG. It's a little quiet here lately? Don't see all the usual suspects I used to see.

What ever happened to Dolf
 

Papa.Smurf0311

Well-known member
you may not need hcg if you return to your trt dose. but then again im not sure since you are going to be using a nandralone. I just got done with a deca and test cycle and it was amazing. i loved it. gained allot of mass and stayed lean. i was always told to run test higher than deca but there are others that say different. i was at 600 test and 350 deca with HCG and an AI and seemed to have a great cycle. Would do it again for sure in the future.
 
you may not need hcg if you return to your trt dose. but then again im not sure since you are going to be using a nandralone. I just got done with a deca and test cycle and it was amazing. i loved it. gained allot of mass and stayed lean. i was always told to run test higher than deca but there are others that say different. i was at 600 test and 350 deca with HCG and an AI and seemed to have a great cycle. Would do it again for sure in the future.

Solid info! thank you!
 
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