hmm not sure. I hope someone else would weigh in on this. BP is something thats hard to manage. if this is your first cycle then dont go over 400. the reason being is because you want your first cycle to be lower so you can always go up from there and get more bang for your buck. if you start at 500 or 600 then thats usually where you start every other cycle. hopefully someone else comments. please get some blood work as well. its worth it. you can even post your results here and get tips. also as in my other comments, look into good OTC supplements. like NAC, CoQ10, Fish oil, tumeric, curccumin. maybe even take low dose asprin before bed but talk to your doctor about that one. some peoples systems dont like asprin.