Absolutely! More gear means higher risks of sides. So if you get a little gyno at 300, you'll get more at 500. If you get some water retention at 300, you'll get more at 500. So starting low, then learning how to manage those sides before adding more.
Like how much Arimidex to use, or when.
Again it's all a big science experiment... we're all learning as we go as far as how each of our bodies will respond to different compounds and doses.
Some people would rather run a compound like eq or mast that helps lower est, than using Arimidex.
But these skills and knowledge only come with time and experience.
That's why its soooooooo important to start low, and go slow!
Now I should also say some people just don't get sides... I've been on test since... August (I think) and I've never taken 1 single peice of Arimidex. I just don't get high est sides.
Then we have maniacs like
@bobby ricky who are running 1,200mg test and 600mg deca and have no sides... but this obviously isn't his first go around.
Everyone is different, no 2 people act the same way to a compound. Hell most people hate tren because of the terrible acne it can cause... yet it's seemed to have fixed mine. My skin has never looked better... no fucking clue why though.
In short... gear isn't the 3 month magic fix most people think it is. Yes it can put mass on quickly with hard work and proper diet. Or it can fuck your whole shit up. Gear like exercise is about the long term. Getting bigger and better over time!